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Search Results for " orally activity "

20

Compounds

Cat No. Product Name Synonyms Targets
T1292 Tiapride hydrochloride Dopamine Receptor
Tiapride is a selective blocker of D2/3 dopamine receptors in the brain. It is used in the therapy of various psychiatric and neurological disorders containing dyskinesia, negative symptoms of psychosis, alcohol withdraw...
T3306 PF-04418948 PF 04418948,PF04418948 Prostaglandin Receptor
PF-04418948 is a potent EP2 receptor antagonist (IC50 = 16 nM for human EP2 receptors). Displays over 2000-fold selectivity for EP2 receptors over EP1, EP3, EP4, DP1 amd CRTH2 receptors; exhibits <30% binding at a divers...
T30937 Cimicoxib UR-8880,UR8880,trade name: Cimalgex COX
Cimicoxib (UR8880) is a potent and selective inhibitor of COX-2 with anti-inflammatory and analgesic activity.
T17158 Trans-AUCB t-AUCB Epoxide Hydrolase
trans-AUCB (t-AUCB) is an effective and selective soluble epoxide hydrolase inhibitor (IC50s: 1.3 nM, 8 nM, 8 nM for hsEH, mouse sEH and rat sEH, respectively).
T12477 Uzansertib phosphate INCB053914 phosphate Pim
Uzansertib phosphate (INCB053914 phosphate) is an orally active, ATP-competitive inhibitor of pan-PIM kinase(PIM1, PIM2, PIM3 with IC50s of 0.24 nM, 30 nM, 0.12 nM , respectively).
T22330 Fenamic acid 2-Anilinobenzoic acid,Diphenylamine-2-carboxylic acid,2-(Phenylamino)benzoic acid,N-Phenylanthranilic acid Chloride channel
Fenamic acid (N-Phenylanthranilic acid) is a chloride channel blocker that causes renal papillary necrosis in rats. Fenamic acid serves as a parent structure for several nonsteroidal anti-inflammatory drugs (NSAIDs), inc...
T0203 Sumatriptan succinate GR 43175 5-HT Receptor
Sumatriptan succinate (GR 43175), a serotonin1 (5-HT1) receptor agonist, is used in the acute treatment of a migraine headache.
T33421 MK-0686 MK0686 Bradykinin Receptor
MK-0686 is an orally available bradykinin B1 receptor antagonist with potential anti-inflammatory activity.
T12847 SB-616234-A SB-616234A 5-HT Receptor
SB-616234A is a selective and orally bioavailable antagonist of 5-HT1B receptor, with anxiolytic and antidepressant activity.
T28911 Tafetinib SIM-010603,SIM010603,SIM 010603 Tyrosine Kinases
Tafetinib (SIM-010603) is a novel potent and orally available tyrosine kinase inhibitor with anti-angiogenic and anti-tumour activity.
T27176 Dimethandrolone Undecanoate DMAU Others
Dimethandrolone Undecanoate (DMAU) is a novel orally available androgen with progestational activity and is a potential male contraceptive compound.
T6153 Icotinib BPI-2009,BPI-2009H,Conmana EGFR
Icotinib (Conmana) is an orally available quinazoline-based inhibitor of epidermal growth factor receptor (EGFR), with potential antineoplastic activity.
T6076 EPZ015666 GSK3235025 Histone Methyltransferase
EPZ015666 (GSK3235025) is an orally available inhibitor of PRMT5 enzymatic activity.
T13639 Deferasirox (Fe3+ chelate) Apoptosis
Deferasirox (Fe3+ chelate) is an orally available iron chelator with potential anticancer activity, inhibits the anti-apoptotic activity of MCL-1, and can be used to study iron overload.
T8432 ASP4132 AMPK
ASP4132 is an orally active AMPK activator (EC50 : 18 nM), has anti-cancer activity.
T6231 Tebipenem Pivoxil ME1211,Orapenem Antibacterial , Antibiotic
Tebipenem Pivoxil (Orapenem) , an orally activity carbapenem antibiotic, is utilized in treating otolaryngologic and respiratory infections.
T27318 Fidexaban CI-1031,BX-807834,PD-200022,CI1031,BX807834,ZK-807834 Factor Xa
Fidexaban (CI1031) is a novel, potent, selective and orally active factor Xa inhibitor that has demonstrated antithrombotic activity in a variety of assays
T14546 Bermoprofen AD-1590,AJ-1590 Others
Bermoprofen (AD-1590) is an orally active non-steroidal anti-inflammatory compound with anti-inflammatory and analgesic activity used in the study of gastric ulcers.
T12862 SC58451 COX
SC58451 is a novel potent, orally active and selective COX-2 inhibitor.SC58451 showed anti-inflammatory activity in a rat model of arthritis.
T16781 Rogaratinib BAY1163877 FGFR
Rogaratinib (BAY1163877) is an aberrant inhibitor of fibroblast growth factor receptor (FGFR). Rogaratinib is as an orally available, selective and potent inhibitor of FGFR-1, -2 and -3 kinase activity.
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