20
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T1292 | Tiapride hydrochloride | Dopamine Receptor | |
Tiapride is a selective blocker of D2/3 dopamine receptors in the brain. It is used in the therapy of various psychiatric and neurological disorders containing dyskinesia, negative symptoms of psychosis, alcohol withdraw... | |||
T3306 | PF-04418948 | PF 04418948,PF04418948 | Prostaglandin Receptor |
PF-04418948 is a potent EP2 receptor antagonist (IC50 = 16 nM for human EP2 receptors). Displays over 2000-fold selectivity for EP2 receptors over EP1, EP3, EP4, DP1 amd CRTH2 receptors; exhibits <30% binding at a divers... | |||
T30937 | Cimicoxib | UR-8880,UR8880,trade name: Cimalgex | COX |
Cimicoxib (UR8880) is a potent and selective inhibitor of COX-2 with anti-inflammatory and analgesic activity. | |||
T17158 | Trans-AUCB | t-AUCB | Epoxide Hydrolase |
trans-AUCB (t-AUCB) is an effective and selective soluble epoxide hydrolase inhibitor (IC50s: 1.3 nM, 8 nM, 8 nM for hsEH, mouse sEH and rat sEH, respectively). | |||
T12477 | Uzansertib phosphate | INCB053914 phosphate | Pim |
Uzansertib phosphate (INCB053914 phosphate) is an orally active, ATP-competitive inhibitor of pan-PIM kinase(PIM1, PIM2, PIM3 with IC50s of 0.24 nM, 30 nM, 0.12 nM , respectively). | |||
T22330 | Fenamic acid | 2-Anilinobenzoic acid,Diphenylamine-2-carboxylic acid,2-(Phenylamino)benzoic acid,N-Phenylanthranilic acid | Chloride channel |
Fenamic acid (N-Phenylanthranilic acid) is a chloride channel blocker that causes renal papillary necrosis in rats. Fenamic acid serves as a parent structure for several nonsteroidal anti-inflammatory drugs (NSAIDs), inc... | |||
T0203 | Sumatriptan succinate | GR 43175 | 5-HT Receptor |
Sumatriptan succinate (GR 43175), a serotonin1 (5-HT1) receptor agonist, is used in the acute treatment of a migraine headache. | |||
T33421 | MK-0686 | MK0686 | Bradykinin Receptor |
MK-0686 is an orally available bradykinin B1 receptor antagonist with potential anti-inflammatory activity. | |||
T12847 | SB-616234-A | SB-616234A | 5-HT Receptor |
SB-616234A is a selective and orally bioavailable antagonist of 5-HT1B receptor, with anxiolytic and antidepressant activity. | |||
T28911 | Tafetinib | SIM-010603,SIM010603,SIM 010603 | Tyrosine Kinases |
Tafetinib (SIM-010603) is a novel potent and orally available tyrosine kinase inhibitor with anti-angiogenic and anti-tumour activity. | |||
T27176 | Dimethandrolone Undecanoate | DMAU | Others |
Dimethandrolone Undecanoate (DMAU) is a novel orally available androgen with progestational activity and is a potential male contraceptive compound. | |||
T6153 | Icotinib | BPI-2009,BPI-2009H,Conmana | EGFR |
Icotinib (Conmana) is an orally available quinazoline-based inhibitor of epidermal growth factor receptor (EGFR), with potential antineoplastic activity. | |||
T6076 | EPZ015666 | GSK3235025 | Histone Methyltransferase |
EPZ015666 (GSK3235025) is an orally available inhibitor of PRMT5 enzymatic activity. | |||
T13639 | Deferasirox (Fe3+ chelate) | Apoptosis | |
Deferasirox (Fe3+ chelate) is an orally available iron chelator with potential anticancer activity, inhibits the anti-apoptotic activity of MCL-1, and can be used to study iron overload. | |||
T8432 | ASP4132 | AMPK | |
ASP4132 is an orally active AMPK activator (EC50 : 18 nM), has anti-cancer activity. | |||
T6231 | Tebipenem Pivoxil | ME1211,Orapenem | Antibacterial , Antibiotic |
Tebipenem Pivoxil (Orapenem) , an orally activity carbapenem antibiotic, is utilized in treating otolaryngologic and respiratory infections. | |||
T27318 | Fidexaban | CI-1031,BX-807834,PD-200022,CI1031,BX807834,ZK-807834 | Factor Xa |
Fidexaban (CI1031) is a novel, potent, selective and orally active factor Xa inhibitor that has demonstrated antithrombotic activity in a variety of assays | |||
T14546 | Bermoprofen | AD-1590,AJ-1590 | Others |
Bermoprofen (AD-1590) is an orally active non-steroidal anti-inflammatory compound with anti-inflammatory and analgesic activity used in the study of gastric ulcers. | |||
T12862 | SC58451 | COX | |
SC58451 is a novel potent, orally active and selective COX-2 inhibitor.SC58451 showed anti-inflammatory activity in a rat model of arthritis. | |||
T16781 | Rogaratinib | BAY1163877 | FGFR |
Rogaratinib (BAY1163877) is an aberrant inhibitor of fibroblast growth factor receptor (FGFR). Rogaratinib is as an orally available, selective and potent inhibitor of FGFR-1, -2 and -3 kinase activity. |